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Quetiapine Fumarate 111974-72-2

Item Code:111974-72-2 Features:In-house; 25kg/drum
  • Description
Quetiapine Fumarate(CAS: 111974-72-2)
  
Appearance
A White or almost white crystalline powder
Solubility
Practically insoluble in water, soluble in glacial acetic acid, sparingly soluble in methanol and ethanol
Melting range
172-176℃
 
Identification
0.1g of sample make the purple of 0.01M potassium permanganate disappear and produce brown precipitation
30μg/ml solution in water shows a max absorption at 289nm
The IR spectrum is concordant with the reference standard
Related substance (HPLC)
Monoethylfumarate: 0.10% max
Piperazinyldibenzothiazepine: 0.10%max
Dibenzothiazepinone: 0.10% max
Hydroxyethylpiperazinyldibenzothiazepine : 0.10% max
Ethylpiperazinyidibenzothiazepine: 0.10% max
Morpholinodibenzothiazepine: 0.10% max
Chlorodibenzothiazepine: 0.10% max
Any other individual impurity : 0.10% max
Total impurities : 0.5% max
PH
5.0-6.0
Loss on drying
0.5% max
Residue on ignition
0.1% max
Heavy metals
0.001% max
Assay (on anhydrous basis)
98.5-101.0%
 

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